I think the biggest advantages to using multiple docs are organizational and mental. Say you have document for each section, it's much easier to find and fix or add to a section if it's in its own document. It's also easier to mentally consume and think about when you open smaller documents than larger ones. If you open a document and the scroll bar starts getting smaller and smaller you start to think how long it'll take to find you you need to change, if it's worth making the change and how long it will take to load. Of course these are all subjective and maybe some people don't have that problem.
Another good reason for multiple documents is if at some future time you decide to split off each section / chapter it is easier to start with multiple documents and include them into one big one than it is to try and chop it up afterwards.
Along with the organizational issue, if you have multiple people working on a document it's easier to see changes in a smaller document than it is one large document.