If your app is relatively straightforward, and it could be e.g. a synchronous CRUD REST app, then actor model may be overkill.
For larger more complex domains, with more moving parts the Actor Model may ease how you think about your app and are able to break it down into constituent parts. There are plenty of architectural considerations and options to take into account, and they largely depend on your specific use cases and non-functional requirements (NFR's).
As @levi-ramsey says in his answer CQRS might be used in addition to actors, but is optional. It is an independent choice to add it. So too are Event Sourcing (ES) and e.g. Domain-Driven Design (DDD).
Some NFR's where actor model is helpful are distribution (location-transparency of actors) and resiliency (delegate to child actors, and "just let them crash" where a supervisor may restart or escalate errors). Actor model may abstract away a lot of network plumbing which is a boon in microservices architectures.
Depending on domain complexity, business logic, need for modularity/extensibility, scalability etc. it makes more sense to combine various architectural practices, such as Actors/DDD/CQRS/ES and hexagonal architecture. But only if your app warrants it.. they each have their pros and cons (like 'eventual consistency' in microservices and event sourcing).
The above combination is found in Distributed DDD (DDDD), also called Reactive DDD. There's some good videos by Vaughn Vernon to be found here e.g. Using the Actor Model with Domain-Driven Design (DDD) in Reactive Systems (he turns domain aggregates into actors), and also Alexey Zimarev in DDD, Event Sourcing and Actors (he places the actor logic in the application layer).
You'll find lots Akka-related material. They have good documentation material. Personally I find proto.actor interesting, created by one of the Akka founders, and with Alexey part of the team.
In terms of design patterns this article Meet the Top Akka.NET Design Patterns is a good start. The Akka documentation has a section on Interaction Patterns. Though I haven't read it, I think Applied Akka Patterns book by O'Reilly is quite good.
In terms of example code the Github actor-model topic may lead to some great projects to learn from, and also e.g. the Proto Actor project has a big list of Golang examples or DotNet examples to apply from, and a Bootcamp course.