So it seems all the major browser vendors are sandboxing the flash plugin, and terminating it after a certain amount of inactivity. This is problematic for developers who connect the Flash Builder Debugger to the browser. If you stand on a breakpoint for more than 45 seconds, it terminates your session.
I've found a config param to change on firefox that disabled this functionality, but i havent found a similar command for Safari/ Webkit / Chrome.
http://kb2.adobe.com/cps/899/cpsid_89943.html
"To prevent Firefox from terminating plug-ins that it considers unresponsive, set dom.ipc.plugins.timeoutSecs to -1 in about:config. For more information, see Plugin hang detector."